General Information

  • ID:  hor004131
  • Uniprot ID:  P85863
  • Protein name:  Schistomyotropin-2
  • Gene name:  NA
  • Organism:  Schistocerca gregaria (Desert locust) (Gryllus gregarius)
  • Family:  Pyrokinin family
  • Source:  animal
  • Expression:  Found in the abdominal ganglia and perisympathetic organs. Not detected in the thoracic ganglia, subesophageal ganglion, corpora cardiaca, corpora allata, hypocerebral ganglion or frontal ganglion.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Schistocerca (genus), Cyrtacanthacridinae (subfamily), Acrididae (family), Acridoidea (superfamily), Acridomorpha, Acrididea (infraorder), Caelifera (suborder), Orthoptera (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  TSSLFPHPRL
  • Length:  10
  • Propeptide:  TSSLFPHPRL
  • Signal peptide:  NA
  • Modification:  T10 Leucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Hindgut‐stimulating activity
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004131_AF2.pdbhor004131_ESM.pdb

Physical Information

Mass: 131503 Formula: C53H83N15O14
Absent amino acids: ACDEGIKMNQVWY Common amino acids: LPS
pI: 10.55 Basic residues: 2
Polar residues: 3 Hydrophobic residues: 3
Hydrophobicity: -28 Boman Index: -1613
Half-Life: 7.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 78
Instability Index: 3710 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  11121115
  • Title:  Pyrokinin Neuropeptides in a Crustacean. Isolation and Identification in the White Shrimp Penaeus Vannamei
  • PubMed ID:  12504101
  • Title:  Mass Spectrometric Analysis of the Perisympathetic Organs in Locusts: Identification of Novel Periviscerokinins